+- AdminClub - Free Web Discussion Forum (https://adminclub.org)
+-- Forum: Webhosting Main Forums (https://adminclub.org/forumdisplay.php?fid=1)
+--- Forum: Dedicated Server Hosting (https://adminclub.org/forumdisplay.php?fid=4)
+--- Thread: Why is Sildigra 100 Mg not suitable for men with severe kidney impairment? (/showthread.php?tid=43178)
Why is Sildigra 100 Mg not suitable for men with severe kidney impairment? - cliffordfosterr - 07-26-2024
Sildigra 100 mg is a medication used to treat erectile dysfunction, and its active ingredient is sildenafil. For individuals with severe kidney impairment, this medication can be problematic for several reasons:
- Metabolism and Clearance: Sildigra 100 mg is primarily metabolized by the liver and excreted by the kidneys. In individuals with severe kidney impairment, the clearance of the drug from the body can be significantly reduced. This means the drug stays in the body longer and can accumulate to potentially harmful levels.
- Increased Risk of Side Effects: Due to the slower clearance of Sildigra 100 mg in patients with severe kidney impairment, there is an increased risk of side effects such as dizziness, headache, flushing, or even more severe reactions. These effects can be exacerbated by the drug’s prolonged presence in the body.
- Dose Adjustment: In cases of severe kidney impairment, the standard dose of sildenafil might be too high because the drug is not excreted efficiently. This can lead to elevated drug levels and a higher likelihood of adverse effects. Dose adjustments are necessary to avoid toxicity, but in severe cases, it may be safer to avoid the medication altogether or use alternative treatments.
- Potential Drug Interactions: Individuals with kidney impairment might be on medications for their condition that could interact with sildenafil. These interactions can further complicate the safe use of sildenafil.