Does Kamagra require sexual stimulation to be effective?

[marwan]

Yes, Kamagra, which contains the active ingredient sildenafil, typically requires sexual stimulation to be effective. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, and its mechanism of action involves increasing blood flow to the penis by relaxing the smooth muscles of the blood vessels. Sexual stimulation is necessary to initiate the release of nitric oxide (NO) in the erectile tissue of the penis, which activates the enzyme guanylate cyclase. Kamagra enzyme increases levels of cyclic guanosine monophosphate (cGMP), leading to relaxation of the smooth muscles and increased blood flow into the penis, resulting in an erection. Therefore, while Kamagra can help facilitate an erection by improving blood flow to the penis, it still requires sexual arousal or stimulation to initiate the physiological processes that lead to an erection. Without sexual stimulation, the medication alone is unlikely to cause an erection.